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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NKX2-4
All Species:
8.48
Human Site:
Y110
Identified Species:
15.56
UniProt:
Q9H2Z4
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H2Z4
NP_149416.1
354
36179
Y110
P
H
G
A
M
G
S
Y
C
N
G
G
L
G
N
Chimpanzee
Pan troglodytes
XP_525278
419
42955
Y175
P
H
G
A
M
G
G
Y
C
N
G
G
L
G
N
Rhesus Macaque
Macaca mulatta
XP_001093634
451
46942
Y207
P
H
G
A
M
G
G
Y
C
N
G
G
L
G
N
Dog
Lupus familis
XP_849082
233
24205
V23
G
G
A
A
A
T
P
V
S
R
F
M
G
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQM3
354
36207
G113
A
M
G
S
Y
C
N
G
G
L
G
N
M
G
E
Rat
Rattus norvegicus
P23441
372
38536
P99
G
N
M
S
E
L
P
P
Y
Q
D
T
M
R
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90788
294
33054
A84
S
Y
G
E
M
D
T
A
K
D
S
K
A
D
K
Frog
Xenopus laevis
P42587
196
22791
Zebra Danio
Brachydanio rerio
Q90481
269
30288
L58
P
L
E
N
V
Q
N
L
P
L
K
N
P
F
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P22808
723
76404
A453
S
R
S
A
D
S
D
A
L
S
V
G
D
A
L
Honey Bee
Apis mellifera
XP_394578
395
41030
Q130
A
T
M
Q
L
T
S
Q
Y
Q
Y
C
A
A
E
Nematode Worm
Caenorhab. elegans
Q9NLC2
299
33058
G89
V
P
G
A
F
P
Y
G
P
G
R
L
P
G
N
Sea Urchin
Strong. purpuratus
NP_999800
411
44821
L150
M
N
M
N
M
S
T
L
S
A
V
G
S
G
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
84.2
77.1
61.2
N.A.
94.3
59.4
N.A.
N.A.
29.9
28.8
31
N.A.
24.3
37.9
31.6
38.9
Protein Similarity:
100
84.2
77.1
62.9
N.A.
94.6
66.4
N.A.
N.A.
42
38.4
42.9
N.A.
32
49.6
43.7
51.3
P-Site Identity:
100
93.3
93.3
6.6
N.A.
20
6.6
N.A.
N.A.
13.3
0
6.6
N.A.
13.3
6.6
26.6
20
P-Site Similarity:
100
93.3
93.3
13.3
N.A.
40
26.6
N.A.
N.A.
33.3
0
20
N.A.
20
13.3
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
8
47
8
0
0
16
0
8
0
0
16
16
0
% A
% Cys:
0
0
0
0
0
8
0
0
24
0
0
8
0
0
0
% C
% Asp:
0
0
0
0
8
8
8
0
0
8
8
0
8
8
8
% D
% Glu:
0
0
8
8
8
0
0
0
0
0
0
0
0
0
16
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
8
0
0
8
0
% F
% Gly:
16
8
47
0
0
24
16
16
8
8
31
39
8
47
0
% G
% His:
0
24
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
8
8
0
0
8
% K
% Leu:
0
8
0
0
8
8
0
16
8
16
0
8
24
0
8
% L
% Met:
8
8
24
0
39
0
0
0
0
0
0
8
16
0
0
% M
% Asn:
0
16
0
16
0
0
16
0
0
24
0
16
0
0
39
% N
% Pro:
31
8
0
0
0
8
16
8
16
0
0
0
16
8
0
% P
% Gln:
0
0
0
8
0
8
0
8
0
16
0
0
0
0
0
% Q
% Arg:
0
8
0
0
0
0
0
0
0
8
8
0
0
8
0
% R
% Ser:
16
0
8
16
0
16
16
0
16
8
8
0
8
0
8
% S
% Thr:
0
8
0
0
0
16
16
0
0
0
0
8
0
0
0
% T
% Val:
8
0
0
0
8
0
0
8
0
0
16
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
8
0
8
24
16
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _